摘要
本文测定哮喘患儿外周血中性粒细胞（ＰＭＮ）受多肽ＦＭＬＰ刺激后呼吸爆发释放超氧阴离子（Ｏ_２）能力的变化，结果表明，发作期哮喘患儿ＰＭＮ－Ｏ_２释放量明显高于对照组健康儿童（Ｐ＜０．０１）；稳定期哮喘患儿ＰＭＮ－Ｏ_２释放量明显低于发作期患儿（Ｐ＜０．０１），但仍高于对照组健康儿童（Ｐ＜０．０５）；内、外源型哮喘患儿ＰＭＮ－Ｏ_２释放量无显著性差异（Ｐ＞０．０５）。提示哮喘患儿ＰＭＮ呼吸爆发功能亢进，其活化及介入的气道炎症是一非特异性炎症过程。
Airway inflammation with neutrophil infiltration plays a core role in airway hyperreactivity,superoxide anion(O2)being one of the important inflammatory mediator. The author investigated the function of peripheral blood neutrophils with respect to O2 generation in asthmatic children. The results showed that O2 generation of neutrophils in asthmatic children(n=35)was significantly higher than that in healthy children(n=32 ) after stimulation with N-FMLP (17. 4±3.9 nmol/106 cells· 5 min-1 versus 10.5±1. 6 nmol /106 cells·5 min-1,p<0.01).There was no significant difference in O2 generation between intrinsic and extrinsic asthmatic children.These results have indicated that neutrophils in asthmatic children could produce more O2 when they are stimulated than do those in healthy children,which might play an important role in the pathogenesis of airway inflammation.
基金
浙江省教委
卫生厅科研基金
