颅脑MRI检查在非乙醇中毒性韦尼克脑病诊断中的价值

Value of cranial MRI on diagnosing nonalcoholic Wernicke's encephalopathy

目的 评价颅脑MRI检查在非乙醇中毒性韦尼克脑病(WE)诊断中的价值。方法 对6例非乙醇中毒性WE患者的临床特征、颅脑MRI影像及治疗转归等资料进行分析。结果 本组颅脑MRI显示,丘脑内侧及侧脑室、第三脑室、中脑导水管周围脑组织对称性T2W及Flair成像异常高信号, 1例成为持续性植物状态的患者伴有部分皮质T2W及Flair成像异常高信号。随访显示4例康复患者,随临床表现好转其颅脑MRI异常信号逐渐消失, 1例持续性植物状态患者随访2年,异常信号无变化。结论 颅脑MRI对非乙醇中毒性WE具有诊断价值,其显示的损害范围可反映WE患者的疾病严重程度。

Objective To evaluate the value of cranial MRI on diagnosing nonalcoholic Wernickes encephalopathy (WE). Methods The clinical characters, cranial MRI features, and outcomes materials in six cases of nonalcoholic Wernickes encephalopathy were analyzed.Results Cranial MR and Flair imaging of the patients exhibited areas of increased T 2W and flair signals symmetrically surrounding the aqueduct and third ventricle and within the medial thalamus. One patient who became persistent vegetative state coexistenced increased T 2W and flair signal of the cortex. According to the follow-up results, the alterations of four patients in T 2W and Flair signals showed to resolve being consistent with the clinical recovery. One patient with persistent vegetative state had no change within two years of the follow-up.Conclusions Cranial MRI is of great value in diagnosing nonalcoholic Wernickes encephalopathy and reflects appropriately the pathological evolution of this disease.