关节软骨病损的磁共振成像及其与大体标本的对照研究

The control study of general sample based on MRI of articulation cartilage erosion

目的: 探讨MR对关节软骨各期病变的敏感成像序列并评价MR对早期软骨病变的诊断价值。方法: 通过1例新鲜截肢患者和4例正常猪膝关节的T2WI、PDWI、GE、STIR、3DFS—FSPGR等序列的成像研究, 选定最佳的序列用于6例猪骨性关节炎(OA) 模型膝关节扫描, 图像与大体标本对照以评价MR对关节软骨的诊断价值。结果: 5种序列的组织分辨力、病变检出率以3DFS—FSPGR序列最高分别达67. 9%和93. 7%, OA模型3DFS—FSPGR图像与大体标本对照Pearson列联系数P=0. 88。结论: 在5种序列中, 3DFS—FSPGR是理想的关节软骨成像序列; MR不仅对中晚期软骨病变有良好显示, 对早期软骨病变也能做出正确诊断。

Objective:To Study the sensitive sequence of MR for all stages of articulation cartilage erosion and to evaluate the effect of MR on the correct diagnosis in the early stage of articulation cartilage.Method:After one human fresh amputation and 4 normal pigs knee joints were studied by T 2WI,PDWI,GE,STIR,3D FS-FSPGR sequences and 6 pigs osteoarthritis(OA) model knee joints were studied by the selected best sequence,MRI images was compared with general samples to evaluate the effect of MR on the correct diagnosis of cartilage.Result:The highest rates of tissue resolution and diagnosis were seen in 3D FS-FSPGR as 67.9% and 93.7% respectively,Pearson index is 0.88.Conclusion:3D FS-FSPGR is a favorable scan sequence to examine the pathological changes of articulation cartilage.MRI can show the pathological changes including early stage and have good veracity to the early pathological changes of articulation cartilage.