摘要
目的寻找合成利奈唑酮的新工艺。方法以(R) 环氧氯丙烷和间氟苯基异氰酸酯为起始原料,经环化、叠氮化、还原、酰化、溴代、缩合反应得到利奈唑酮。结果与结论成功地合成出利奈唑酮,总收率由文献的11 .3%提高到4 3. 2 % ,而且操作简单,成本低廉。
Aim To find a new synthetic method of linezolid.Methods Starting with 3-fluorophenyl isocyanate and(R)-epichlorohydrin,linezolid was synthesized through cyclization,substitution,acylation,bromination,and condensation.Results and conclusion Linezolid was successfully synthesized in a total yield of 43.2% with the advantages of low cost and simple processing in comparison with the reported yield of 11.3%.
出处
《中国药物化学杂志》
CAS
CSCD
2005年第2期89-90,93,共3页
Chinese Journal of Medicinal Chemistry
关键词
药物化学
化学合成
利奈唑酮
medicinal chemistry
chemical synthesis
linezolid
