摘要
9(S) - 红霉胺是合成地红霉素和CP -5 4 4 372的中间体,此化合物可在超声波的作用下利用NaBH4/ZrCl4于室温下还原9(E) - 红霉素肟制得,收率为6 9% ,其结构经IR、NMR和MS确证。该方法是制备9(S) - 红霉胺的方便、有效的途径。
S)-Erythromycylamine,the useful synthetic intermediate of dirithromycin and CP-544372,was synthesized by selective reduction of erythromycin A 9(E)-oxime with NaBH_4/ZrCl_4 under ultrawave mediated at room temperature in 69% yield and its structure was characterized by IR,NMR and MS.The present method was proved to be a more convenient and effective approach to obtain 9(S)-erythromycylamine.
出处
《中国药物化学杂志》
CAS
CSCD
2005年第2期113-115,共3页
Chinese Journal of Medicinal Chemistry
基金
TheprojectwassupportedbyLiaoningBureauofScience&Technology(2 0 0 2 10 2 8) ,LiaoningBureauofEducation(2 0 2 0 4 32 38)andShenyangBureauofScience&Technology(0 2Z0 10 6 0 ) .
关键词
药物化学
工艺改进
还原反应
红霉胺
超声作用
medicinal chemistry
process improvement
reduction reaction
erythromycylamine
ultrasond irradiation
