急性冠脉综合征患者血清肿瘤坏死因子-α和C反应蛋白含量变化及临床意义

Clinical significance of the changes of serum tumor necrosis factor-a and C-reactive protein levels in patients with acute coronary syndrome

目的探讨急性冠脉综合征(ACS)患者血清肿瘤坏死因子α(TNF-α)和C反应蛋白(CRP)含量的变化及临床意义。方法检测50例ACS患者(ACS组)、50例稳定型心绞痛(SAP)患者(SAP组)及50例健康体检者(对照组)血清TNF-α、CRP水平,并比较各组之间的差异,以及TNF-α和CRP 的相关性。结果ACS组血清TNF-α、CRP水平明显高于SAP组和对照组(P<0.01),而在ACS组中,急性心肌梗死(AMI)患者又高于不稳定型心绞痛(UAP)患者(P<0.05);SAP组与对照组差异无显著性(P>0.05);血清TNF-α与CRP水平呈正相关(r=0.5246,P<0.01)结论血清TNF-α、CRP与ACS 的发生有关,其水平反映ACS的严重程度。

Objective To investigate the clinical significance of the changes of serum tumor necrosis factor (TNF-α) and C-reactive protein (CRP) levels in patients with acute coronary syndrome (ACS) .Methods The serum levels of TNF-α and CRP were detected in 50 patients with ACS (ACS group) ,50 patients with stable angina pectoris (SAP group) and 50 healthy subjects(control group). Results The serum levels of TNF-α and CRP in ACS group were higher than those in SAP group and control group ( P < 0.01); among the patients with ACS, the serum TNF-α and CRP levels in AMI patients were higher than those of UAP group ( P < 0.05) .There was no significant difference in the levels of TNF-α and CRP between SAP group and control group ( P > 0.05) .There was a positive correlation between TNF-α and CRP levels ( r = 0. 5246, P < 0.01). Conclusion TNF-α and CRP are correlated with pathogenesis of ACS and may reflect the seventy of ACS.