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ICAT蛋白在抑制肿瘤作用中的新进展

The latest development of the research on ICAT's tumor-inhibiting mechanism
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摘要 Wnt信号传导途径的调控失常是导致多种类型的细胞发生癌变的主要原因之一,该途径成员之一beta-连环蛋白/T细胞因子4的激活可促进癌变,而另一成员ICAT通过阻止beta-连环蛋白/T细胞因子4复合物的形成而对Wnt信号传导途径进行负调控来发挥抑癌作用。现综述ICAT蛋白抑瘤机制新进展。 The abnormity of Wnt signaling transduction pathway is one of the major causes of the occurrence of many types of cancer cells.While one of the pathway components,beta-cate nin/TCF-4,when activated,can facilitate cancerization,the other pathway component ICAT,which prevents the formation of the compound of beta-catenin/TCF-4,can negatively regulate the activity of the Wnt pathway and thereby inhibit cancer.The latest development of the research on ICAT's cancer-inhibiting mechanism was reviewed.
作者 任静 曾昭淳
机构地区 重庆医科大学生物化学教研室
出处 《生物学杂志》 CAS CSCD 2005年第2期10-11,共2页 Journal of Biology
关键词 Wnt信号传导途径 beta-连环蛋白/T细胞因子4 ICAT Wnt signaling transduction Pathway beta-catenin/TCF-4 ICAT
分类号 Q591.2 [生物学—生物化学]
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参考文献10

  • 1Tago K,Nakamura T,Nishita M et al. Inhibition of Wnt signaling by ICAT, a novel β- catenin- interacting protein[ J ]. Genes Dev, 2000 Jul 15 : 14(14) : 1741 - 9.
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生物学杂志
2005年 第2期

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