糖尿病患者伴抑郁状况的多因素分析

Multivariate analysis of patients with diabetes mellitus accompanied by depression

目的:调查糖尿病患者抑郁的患病率,分析与抑郁相关的危险因素,探讨糖尿病与抑郁之间的相互关系。方法:纳入2004-05/06在哈尔滨医科大学附属第二医院内分泌科住院的80例糖尿病患者,男36例,女44例,年龄(55±12)岁,病程(7±6)年,用Zung抑郁自评量表进行抑郁评分,抑郁总分≥40分者诊断为抑郁。同时采集身高、体质量、体质量指数、病程、并发症数目、临床代谢指标、糖尿病家族史,以及收入状况、血型等。计算抑郁的患病率,用统计学方法(t检验、卡方检验、Logistic回归)分析糖尿病合并抑郁的危险因素。结果:80例糖尿病患者中患抑郁者24例,糖尿病抑郁患病率为30%,高于正常人群。不同性别、病程、糖化血红蛋白、血压、及并发症的患者抑郁患病率差异有显著性意义(P<0.05)。结论:性别、病程、血压、糖化血红蛋白和并发症数目与抑郁密切相关,是糖尿病合并抑郁的独立危险因素。

AIM: To investigate the prevalence rate of depression in patients with diabetes mellitus (DM), analyze the risk factors related to depression, and study the relationship between depression and diabetics.METHODS: Eighty DM inpatients (36 males and 44 females) aged (55±12) years with disease course of (7±6) years, who were hospitalized in the Department of Endocrinology, the Second Affiliated Hospital of Harbin Medical University between May and June 2004, were assessed with the Zung self rating depression scale (SDS), and those with total score of depression ≥40 were diagnosed to have depression. Meanwhile, the demographic data were collected, such as body height, body mass, body mass index(BMI), disease course, number of complications, clinical metabolic index, family history of DM, income status and blood type.The prevalence rate of depression was calculated, and the risk factors for DM patients accompanied by depression were analyzed statistically (student’s t test,chi square test and Logistic regression).RESULTS: Twenty four cases had depression among the 80 DM patients, and the prevalence rate of diabetic depression was 30%, which was higher than that in the normal subjects. There were significant differences in the prevalence rate of depression among patients of different gender, and those with different disease course, glycosylated hemoglobin A(HbA1c), blood pressure and number of diabetic chronic complications (P< 0.05).CONCLUSION: Gender, disease course,blood pressure,HbA1c and number of diabetic chronic complications are closely correlated with depression,and they are the independent risk factors of DM accompanied by depression.