盐酸氟西汀并心理行为校正儿童注意力缺陷障碍伴多动症的效应

Interventional efficacy of fluoxertine hydrochloride combined with psychobehavioral corrective therapy in children with attention deficit hyperactivity disorder

目的:探讨盐酸氟西汀合并心理行为干预对儿童多动症的治疗效果,以期为早期干预提供依据。方法:将2002-01/2003-01在重庆医科大学附属北碚医院门诊就诊的儿童多动症患儿50例进行12周盐酸氟西汀合并心理行为干预,并通过儿童行为量表和48项儿童行为问卷观察,及脑电图的改变。结果:治疗前后儿童行为量表中抑郁焦虑、社交退缩、躯体主诉、思维问题、注意缺陷、社交问题,违纪行为、攻击行为差异有显著性意义(P<0.01或0.05)。治疗前后48项儿童行为问卷中品行问题、学习问题、心身问题、冲动、多动指数、纠正总分差异有显著性意义(P<0.01)。治疗前后脑电图的改变差异有显著性意义(P<0.05)。结论:盐酸氟西汀胶囊合并心理行为干预对儿童多动症的治疗有较好的效果。

AIM: To investigate the therapeutic effect of fluoxertine hydrochloride combin ed with psychobehavioural intervention on children with attention deficit hypera ctivity disorder (ADHD), so as to provide evidence for early interventions. METHODS: Fifty ADHD children received treatment of fluoxertine hydrochloride c ombined with psychobehavioural intervention for 12 weeks in the out patient dep artment of Beibei Hospital affiliated to Chongqing University of Medical Science s from January 2002 to January 2003, and they were assessed with AchenRbach chil d behaviour checklist (CBCL) and 48 item child behaviour questionnaire, and the changes of electroencephalogram (EEG) were observed. RESULTS: There were significant differences in the scores of depressive anxiet y, social withdrawal, somatic complaints, thinking problems, attention deficit, problems in social intercourse, delinquent behavior and aggressive behavior in t he Achenlach CBCL before and after treatment (P< 0.01 or 0.05).Significant diffe rences were also observed in the scores of behavioral, learning and psychosomati c problems, impulsion, anxiety, hyperactive index and corrective total score in the 48 item child behaviour questionnaire before and after treatment(P< 0.01). EEG was significantly changed before and after treatment (P< 0.05). CONCLUSION: Fluoxertine hydrochloride combined with psychobehavioural interven tion has good efficacy in treating ADHD children.