兰索拉唑法莫替丁和莫沙比利联合治疗反流性食管炎

Combination of Lansoprazole Famotidine and Mosapride in Treatment of Gastroesophageal Reflux Disease

目的观察兰索拉唑、法莫替丁和莫沙比利联合治疗反流性食管炎的临床疗效。方法46例反流性食管炎随机接受兰索拉唑、法莫替丁和莫沙比利联合治疗或仅服用雷尼替丁治疗。4周后观察临床症状,并经胃镜检查观察食管炎变化。结果经4周治疗发现,联合治疗组患者明显改善临床症状、如反酸、心、胸骨后疼痛等。食管炎症分级也有明显降低(P<0.05)。结论兰索拉唑、法莫替丁和莫沙比利联合应用有效地控制胃酸和胆汁的反流,是治疗反流性食管炎的一种有效、价廉的方法。

Objective To evaluate clinical effects of lansoprazole, famotidine and mosapride on the treatment of gastro-esophageal reflux disease (GERD). Methods 46 patients with GERD were randomly treated with a combination of lansoprazole, famotidine and mosapride or with ranitidine alone. Clinical effects and inflammatory lesions in lower esophagus were analyzed 4 weeks after systemic treatment. Results Clinical symptoms including acid regurgitation, heartburn, retrosternal pain were significantly relieved 4 weeks after systemic treatment. Inflammatory lesions in lower esophagus were also markedly improved (P < 0.05). Conclusion A combination of lansoprazole, famotidine and mosapride is an effective way to treat GERD.