辛伐他汀在急性冠脉综合征中的应用

Applieation of simvastatin in patients of acute coronary syndrome

目的 观察辛伐他汀在治疗急性冠脉综合征(ACS)中的治疗作用。方法 将10 0例ACS患者随机分为两组:辛伐他汀治疗组(辛伐他汀+常规治疗,即治疗组)和常规治疗组(对照组) ,每组5 0例,观察用药前后血脂变化及主要心血管事件发生情况。结果 对照组治疗前后血脂无显著改变(P >0 .0 5 )。治疗组经辛伐他汀治疗10周后,血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL C)水平明显降低,高密度脂蛋白胆固醇(HDL- C)水平略有上升,明显降低心血管事件发生率(χ2 =4 .6 8,P <0 .0 5 ) ,治疗前后肝肾功能无明显变化。结论 他汀类药物治疗ACS能显著改善临床症状,延缓动脉硬化的发展,降低ACS早期临床事件发生率。

Objective To observe the ther ap eutic effect of simvastatin in patients of acute coronary syndrome(ACS). Methods One hundred ACS patients were randomily divided into two groups :simvastin group (treatment group) and routine therapy group(control group),each group had fifty patients.Results After ten weeks simvastatin t reatment,the levels,of blood cholestemia (include TC、TG、LDL) and the incidence rates of major cardiac events in treatment group had apparently decreased.Whereas the HDL-C level had a litt le increased.liver and renal funeticn had no signiticant change before and after treatment between the two groups.Conclusion Simvastatin can si gnificantly inprove the clinical symptoms and redure the incidence rates of majo r cardiac events in the patients of ACS.At the same time,it can delay the develo pment of atherosclerosis.