子宫内膜癌中P16^(INK4a)和CyclinD1基因的表达及临床意义

Expression of P16^(INK4a) and CyclinD1 in endometrial carcinoma and their clinical significance

目的 研究P16INK4a和CyclinD1 在子宫内膜癌中的表达及临床意义, 并探讨两者表达的相关性。方法 采用免疫组化SP法检测58例子宫内膜癌中P16INK4a和CyclinD1蛋白的表达。结果 P16INK4a、CyclinD1蛋白的阳性表达率分别为32 76%、51 72%, 两者的表达均与临床分期有关(P<0 05), P16INK4a蛋白表达还与组织学分级有关(P<0 05); P16INK4a和CyclinD1 蛋白的表达呈负相关(r=-0 428, P<0 01)。结论 P16INK4a和Cy clinD1与子宫内膜癌的发生和发展有关, 且两者存在协同作用。

Objective To investigate the expression of P16 INK4a and CyclinD1 in endometrial carcinoma and their clinical significance,and to assess the correlation between their expression status.Methods\ Immunohistochemical method was used to detect P16 INK4a and CyclinD1 expressions in 58 cases of endometrial carcinoma.Results\ The positive rate of P16 INK4a was 32 76% and its expression was related to histological grade and clinical stage( P <0 05).The positive rate of CyclinD1 was 51 72%.The CyclinD1 expression was associated with clinical stage( P <0 05).There was an inverse correlation between P16 INK4a and CyclinD1( r =-0 428, P <0 01).Conclusion\ P16 INK4a and CyclinD1 have synergistic effect and may play an important role in the development and progression of endometrial carinoma.