电针对红霉素引起家兔胃肠电紊乱的调整作用

Regulating Effect of Electro-acupuncture on Dysrythmia of Gastro-colonic Electric Activity Induced by Erythromycine in Rabbits

在20只家兔记录胃结肠肌电活动。静脉注射红霉素建立胃肠道紊乱模型。研究电针对胃肠电活动的调整效应，观察切除膈下迷走神经后对电针效应的影响。空腹正常家兔胃电频率4．47±1．23cpm，幅值1．90±0．27mV。近端结肠电频率为8．33经±2．61cpm，幅值0．51±0．12mV，远端结肠电频率为674±2．68cpm，幅值0.35±0．1mV。注射红霉素（7mg/kg）后经3．8±1．4min潜伏期，持续36．5±4．5min的胃结肠电频率、幅值增高，出现巨大收缩波。电针足三里后可使胃肠电频率幅值下降，潜伏期和持续期缩短，离散度减小，降低巨大收缩波出现。切除迷走神经后电针效应不明显，胃肠电更为紊乱，说明迷走神经在针刺调整效应中起重要作用。

The myoelectric activity of gastro-colon was recorded in 20 rabbits. The model of gastro-colonic disorder was preduced by vena injection of erythromycine (EM) (7mg/kg). We investigated regulating effect of electro-acupuncture (EA) on the disorder of gastrocolonic electric activity (GEA). After the vagotomy the effect of EA was observed. In fasting and anaesthetic rabbits, the frequency and amplitude of GEA were 4. 47±1. 23 cmp, 1. 90±0. 27 mV at antrum, 8. 33±2. 61 cpm, 0. 51±0.12 mV at ascending colon, 6. 74±2. 68 cpm, 0. 35±0. 10 mV at descending colon. After injection of EM, the frequency and amplitude of GEA were increased, the latency and duration of EM effect were 36. 5±4. 5 min and 3. 8±1. 4 min, the great contraction wave was showed. EA could shorten the duration and latency, decrease the frequency, amplitue and variation coefficient of GEA. After vagotomy the effect of EA disappeared. These results indicate that vagus nerve plays an important role in regulating effect of EA on gastro-colonic disorder