甲氧氯普胺加强电针镇内脏痛及其中枢机制

Potentiation of Eletroacupuncture Analgesia on Visceral pain by Metoclopramide and its Mechanism

为进一步了解中枢DA系统与针刺镇痛的关系，寻找合理的加强针刺镇痛的药物，本文在家免内脏痛模型上观察了甲氧氯普胺对电针镇内脏病的影响。实验结果表明：甲氧氯普胺能够加强电针镇内脏病，并延长其后效应，该作用与阻断脑内DA受体有关。

The present study was to investigate the effect of metoclopramide (MCP) on eletroacupuncture analgesia (EAA) and its mechanism on a rabbit visceral pain model. The results showed that MCP 8mg/kg iv could potentiate EAA and prolong the analgesic duration. The potentiation effect could be attenuated by icv apomorphine (APO) (a mixed D1/D2 agonist). The analgesic duration was shortened by icv SKF38393 (a selective D1 agonist) or LY171555 (a selective D2 agonist). Using HPLCECD, we also found that the HVA content in CSF significantly increased at 20 min. after electroacupuncture (EA) or MCP 8mg/kg iv(P<0.05), but the change of HVA content was not significant when EA and MCP 8mg/kg iv were used together. All these observations indicate that MCP have effects of potentiating EAA and prolonging analgesic duration. These effects are related to the blockade of the central DA receptor. The activations of D1 or D2 receptor is unfavourable to the expression of EA after effect