摘要
利用我们建立的S－180抗阿霉素抗药细胞荷瘤BABL／c小鼠，艾灸关元穴可对多药抗药基因产物（P－170）糖蛋白泵出药物功能有微弱的抑制。艾灸能显著增加钙通道抑制剂异博定对泵出药物功能的抑制作用，这种作用只在允许药物剂量范围才显示出来，当剂量大于允许范围时，效果就不明显。此研究不仅为从分子水平探索针灸的作用机理研究开拓新途径，而且在临床上对克服化疗中的抗药性具有应用前景。
The experiments were performed on BABL/c mice with S-180R adriamycin resistant tumor cells. This animal model was used to analyze the drug accumulation in the S-180R cells by flow cytometer. The drug accumulation presents the pump activity of multidrug resistance (MDR) gene product P-glycoprotein (P-170) in the cell memberane, A weak inhibition was found when moxibustion at Guan-Yan point alone. And a very significant inhibition was observed in the presence of lowdosageof verapanlil, but not at high dose. This study may develop a new way to research the mechanism of actlpuncture and moxibustion at molecular level,and may be useful to overcome the anticancer drug resistance.
出处
《针刺研究》
CAS
CSCD
1994年第2期69-71,共3页
Acupuncture Research
基金
国家自然科学基金
