胸髓蛛网膜下腔微量注射酚妥拉明对电针效应的影响

Influence of Thoracic Spinal Subarachnoid Microinjection of Phentolamine on the Effect of Electroacupuncture

在乌拉坦-氯醛糖麻醉的42只家兔上，观察了胸髓蛛网膜下腔微量注射酚妥拉明（Phen200μg／20μl）对电针“内关”效应的影响，结果表明：1）电针“内关”穴区可明显促进急性心肌缺血（AMI）后ST段、T波、血压的恢复；2）Phen对AMI后ST、T值的恢复没明显影响，而阻止了血压的恢复；3）给酚妥拉明后显著削弱或消除电针“内关”促进ST、T及血压恢复的作用。这表明，胸髓内α受体参与电针“内关”改善AMI的作用，提示胸髓上段是内关－心脏相关联系的环节之一。

The influence of thoracic spinal subarachnoid microinjection of Phentolamine (Phen, 200ug/20ul)on the effect of electroacupuncture. (EA) at Neiguan (PC 6) was observed in 42 urethan-chloralose anesthetized rabbits. Results showed that: 1) EA of Neiguan((PC 6) could significantly promote recovery of elevated ST-segments and T-waves of electrocardiogram induced by acute myocardial ischemia (AMI). 2) subarachnoid microinjection of phentolamine had no marked influence on recovery of ST-segments and T-waves, but impeded recovery of blood pressure of post-AMI; 3 and 3) subarachnoid microinjection of phentolamine could significantly weaken or eliminate the effect of EA of Neiguan(PC 6) in accelerating recovery of ST-segments and T-waves of post-AMI. It denotes that αreceptors of intra-thoracic spinal cord participate in the action of EA of Neiguan(PC 6) in improving AMI, and the upper thoracic segment of the spinal cord is one of the links for connecting Neiguan and the heart.