电针对刺激家兔下丘脑外侧区引起胃机能亢进的调整作用

Regulative Effects of Electroacupuncture on Gastric Hyperfunction Induced by Electrostimulation of the Lateral Hypothalamus Area of Rabbits

本文观察了电针对刺激家兔丘脑外侧区（LHA）引起亢胃效应的调整作用，以探讨针刺抑制肥胖患者食欲和减轻饥饿感的机理。结果提示：针刺对由于LHA兴奋引起的胃机能亢进有明显的抑制作用（P＜0.05或P＜0．01），其作用时间较长，提示该作用有体液因素的参与。β受体阻断剂能显著抑制针刺的作用，提示针刺效应与交感神经功能有关，电针足三里只对刺激LHA引起的亢胃效应起显著抑制作用，提示其具有抗胆碱作用，该作用可能通过兴奋β受体达到抑制食欲，消除饥饿感的作用。

This paper reported our observation of the action of acupuncture on the change of gastric function induced by the excitation of the lateral hypothalamus area (LHA,the feeding center),and research on the mechanism of the acupuncture to inhibiting excessive appetite and reduceing hunger in obese people. Electroacupuncture at Zusanli (ST 36) or Neiting (ST 44) could inhibit the hyperactivity of the stornach induced by stimulation of LHA (P<0.05,P<0.01). The electroacupuncture effect on LHA remained statistically significant (P<0.05, P<0.01)0. 5 ~ 2. 5 hours after acupuncturing. The α-receptor blocking agent phentolamine (1mg/kg )was not distinctly affected (P>0.05) on the inhibition of electroacupuncturing Zusanli (ST 36)to restrain the hyperactivity of the stomach induced by stimulation on LHA; But β-receptor blocking agent propranolol (0. 3mg/kg) could obviously inhibit the effect of electroacupuncturing Zusanli (ST 36) to restrain hyperactivity of stomach triggered by excitation of the LHA. The result shows that electroacupuncture obviously inhibits gastric hyperfunction caused by exccitation of the LHA,for as long as over 3 hours, thus indicating the participation of the humoral factors. Since the electroacupuncture at Zusanli (ST 36) only inhibits gastric hyperfunction caused by excitation of the LHA,it is suggested that the electroacupuncture has an anticholinergic effect through the gastric β receptor, therefore it inhibits the appetite, relieves hunger and reduces body weight in obese people.