摘要
目的:研究脑康宁(川芎、丹参、水蛭等)对脑缺血的保护作用。方法:采用结扎小鼠双侧颈总动脉和迷走神经的方法、高压密闭缺氧法,观察脑康宁对小鼠耐脑缺血、耐缺氧能力的影响;通过阻断大脑中动脉 (MCAO)造成局灶性脑缺血,观察脑康宁对大鼠缺血性脑组织中SOD活性及MDA含量和血清中NO含量、CK活性的影响。结果:发现脑康宁可显著地提高小鼠对脑缺血的耐受力、明显延长耐缺氧时间;增强脑组织中SOD的活性和降低MDA的含量;降低血清中NO含量和CK活性的作用。结论:脑康宁对脑缺血具有显著的保护作用。
AIM: To study the protective effects of Naokangning (Rhizoma Chuanxiong, Radix salviae miltiorrhizae, Hirudo, etc.) against cerebral ischemia. METHODS: We observed the effect of Naokangning on mice's resistance to cerebral ischemia when bilateral common carotid arteries and vagus nerves were ligated and hypoxia under normal pressure and airtight circumstance; With the model of partial cerebral ischemia by blocking rats'middle cer ebral artery (MACO):the effects of Naokangning on the activity of superoxide dismutase (SOD) and creatine kinas e(CK), the content of malondialdehyde (MDA) and nitric oxide (NO) were measured. RESULTS: Naokangning significantly raised mice's ability of anti-cerebral ischemia and prolonged span of life in hypoxia, Moreover, it also obviously improved the activity of SOD, reduced content of MDA in cerebrum, content of NO and activity of CK in blood serum after ischemia. CONCLUSION: Naokangning could strikingly protect brain caused by cerebral ischemia.
出处
《中成药》
CAS
CSCD
北大核心
2005年第4期446-448,共3页
Chinese Traditional Patent Medicine
基金
山东省卫生厅科学基金资助项目(No. 2001CA1CAB1)
