摘要
目的:研究花椒毒酚(XT)抑制豚鼠心肌收缩力的作用机理。方法:采用张力描记法测定离体豚鼠左房肌的收缩力。结果:XT明显抑制豚鼠左房肌的正阶梯现象和静息后增强效应。钙通道阻滞药维拉帕米对正阶梯现象的抑制作用较XT为强,并可使正阶梯现象翻转,但对静息后增强效应无明显影响。XT对哇巴因的正性肌力作用及随后出现的心肌收缩力降低的毒性反应均有明显的对抗作用。结论:XT通过阻滞豚鼠左房肌的电压依赖性和受体调控性钙通道而发挥抑制心肌收缩力的作用。
Objective: To study the mechanism of depressant effect of xanthotoxol(XT) on contractility in the isolated guinea pig atria. Methods: The contractile force of the isolated left atria was determined by tension recording method.Results: In the experiments on contractility of the left atria XT and Verapamil(Ver) significantly depressed the positive staircase phenomena, which was reversed by Ver but not by XT. However, the post-rest potentiation of myocardial contraction in the left atria was only markedly decreased by XT but not by Ver. Furthermore, XT not only attenuated the positive inotropic action, but also delayed the following toxicity response induced by ouabain in the isolated left atria. Conclusion: XT blocked not only the voltage dependent calcium channel, but also the receptor operated calcium channel in the isolated guinea pig atria.
出处
《中药材》
CAS
CSCD
北大核心
2005年第4期319-321,共3页
Journal of Chinese Medicinal Materials
基金
江西省科技厅科技计划资助项目 (No 20021031001 )
江西省教育厅科学技术研究项目(赣教计字 2000 254号)
