非光气法合成吡唑磺酰氨基甲酸酯

Synthesis of ethyl 5-[(methoxycarbonyl)aminosulfonyl]-1-methy- pyrazole-4-carboxylate by non-phosgene method

报道了一种非光气法合成除草剂吡嘧磺隆中间体5 [ (甲氧羰基)氨基磺酰基] 1 甲基吡唑4 羧酸乙酯(简称吡唑磺酰氨基甲酸酯)的新方法,由碳酸二甲酯与5 氨基磺酰基1 甲基吡唑4 羧酸乙酯(简称吡唑磺酰胺)在甲醇钠存在下反应制得产品, 收率85%。产品的结构经元素分析、IR、1HNMR等证实, 并对反应进行的可能机理进行了探讨。结果表明新方法具有反应条件温和、操作安全、简便、收率高的优点。

A new method of synthesis of ethyl 5-[(methoxycarbonyl)aminosulfonyl]-1-methy-pyrazole-4-carboxylate was reported.Using ethyl 5-aminosulfonyl-1-methyl-pyrazole-4-carboxylate and dimethyl carbonate as starting materials.The yield is 85%.The product was confirmed by elemental analysis,IR and 1H NMR.The possible (mechanism) of reaction was discussed.The results show that this new method has many advantages,such as moderate (reaction),the easy and safety operate conditions and high yield.