环丙沙星静脉滴注加口服治疗尿路感染疗效观察

目的依据 PASME 理论设计环丙沙星的给药方案,经临床验证其疗效、细菌清除率、不良反应发生率及费用指标。方法 40例泌尿系感染患者,治疗组20例,每天上午静脉滴注乳酸环丙沙星注射液0.2g(100ml),12～14h 后口服盐酸环丙沙星片0.25g;对照组20例,静脉滴注乳酸环丙沙星注射液0.2g(100ml),bid,疗程均为3～14天。结果治疗组与对照组的总有效率均为100%,痊愈率分别为85%(17/20)与90%(18/20),无显著性差异,P>0.05;两组的细菌清除率均为95%;不良反应发生率两组虽无显著差异,但治疗组每日减少一次输液使注射部位静脉刺激症状发生次数减少50%,同时也使不溶性微粒进入体内的机会减少50%,热原反应发生的可能性减少50%;治疗组亦节省治疗费用37%。结论静脉滴注加口服给药方案安全、有效、经济且方便,值得推广使用。

Objective To design the new administration of Ciprofloxacin on the basis of PASME and evaluate the clinical efficacy,safety, and economic consumption.Method A total of 40 patients of urinary system infection were randomly divided into two groups:20 patients in the trial group received Ciprofloxacin injection 0.2g i.v.gtt.Every morning,Ciprofloxacin tablet 0.25g p.o.after 12～14h;20 patients as the con- trol group received Ciprofloxacin injection 0.2g i.v.gtt.b.i.d.both for 3～14 days.Results In the trial and control groups,the total effective rate were 100% and 100%,the recover rate were 85% and 90%,there was no significant difference between the two groups(P>0.05).But the number of times in which the vein irritation occurs is reduced by 50% and the possibility that insoluble microsomes enter the body is cut down by 50% with economic expenses reduced by 37% in the trial group.Conclusion The new administration of infusion and oral alternant is safe,ef- fective,economical and convenient,so it is worth to popularize.