α-生育酚琥珀酸单酯制取工艺研究

Study on the Process of Producing α-tocopherol Acid Succinate

α-生育酚琥珀酸单酯是维生素E商品的一种,具有多种药理功能。本文通过单因素实验和正交实验,研究了利用人工合成的α-生育酚和琥珀酸酐制取α-生育酚琥珀酸单酯的工艺。在优化工艺条件下,α-生育酚的酯化率达90%以上。

α-Tocopherol acid succinate is one of the important Vitamin E products and has a number of medical functions. This paper outlines the process development of α-tocopherol acid succinate synthesis by a single factor and orthogonal design experiments in which α-tocopherol reacted with the succinic anhydride. With this process, the esterification of α-tocopherol could exceed 90% by weight under optimum conditions.