彭水县2001至2002年钩端螺旋体病血清流行病学监测分析

Sero-Epidemiological Investigation of Leptospirosis in Penshui County in 2001-2002 Years

利用显微凝集试验调查重庆市彭水县2001-2002年495名健康人群血清钩端螺旋体抗体水平.结果显示:健康人群阳性抗体率平均达到61.27%,与性别、年龄、职业有相关性;检测人群中含12群钩体血清抗体,滴度一般在1:20～1:320之间处于较低水平;阳性血清中2001年以56604拜伦型居多占阳性血清的59.8%,而在2002年以56007澳洲型居多占阳性血清的69.9%.以上结果提示彭水县人群存在钩体的隐形感染,但免疫水平低下,且可能有菌群更迭现象存在.

In 2001-2002 years, 495 serum samples were collected from healthy people, and were tested for antibodies to 15 Leptospira serovars using the microscopic agglutination test (MAT). It was greatly useful in the prevention of leptospirosis in Pengshui County. The results showed that 304 cases were positive(61.27%), and 12 serological serovars were found, the predominant serovars was serovar Ballum in 2001(59.8%) and serovar Australia (69.9%) in 2002, and the antibody titer was low between 1∶20 and 1∶320. The results indicated that recessive infection of leptospirosis exists in healthy people with low immunity level, and there may be serovar alternation of Leptospira Interrogans in recent years. So the surveillance of leptospirosis needs to be strengthened and a multi-strains vaccines strategy needs to be developed in Pengshui County.