IL-1β导致的免疫凋亡在2型糖尿病发病中的作用
摘要
白细胞介素(IL)-1β是导致1型和2型糖尿病β细胞凋亡的关键细胞因子。高血糖、肥胖、脂代谢紊乱等是2型糖尿病中影响IL-1β升高的主要因素,其中诱导凋亡的机制涉及一氧化氮合酶、核因子κB等信号转导途径。深入研究IL-1β在2型糖尿病发病中的作用,从免疫学的角度研究2型糖尿病的发生、发展,将有助于开发防治2型糖尿病的新药。
出处
《国外医学（内分泌学分册）》
2005年第B04期13-15,共3页
Foreign Medical Sciences(Section of Endocrinology)
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