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Galectin-3与糖尿病慢性并发症 被引量：2

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摘要 Galectin3即半乳糖凝集素3,它可以通过碳水化合物结合域与细胞表面和基质糖蛋白的β半乳糖苷残基相互作用,并可以通过N段区域形成肽肽结合。这些结构特性使galectin3具有多种功能:细胞黏附的调节、细胞周期的调控、mRNA剪切功能、与晚期糖基化终末产物(AGEs)高亲和力结合等。它在糖尿病慢性并发症的靶组织中均有表达,可能通过调节AGEs受体介导的效应和组织重构过程促进糖尿病慢性并发症的发展,也可以通过参与AGEs的清除而对靶组织损伤起保护性作用,在糖尿病慢性并发症的发生、发展中起着重要的作用。
作者 马婵娟 金晖 孙子林
机构地区 东南大学附属中大医院内分泌科
出处 《国外医学（内分泌学分册）》 2005年第B04期21-24,共4页 Foreign Medical Sciences(Section of Endocrinology)
关键词 GALECTIN-3 糖尿病 并发症 细胞周期 细胞黏附
分类号 R587.2 [医药卫生—内分泌]
  • 相关文献

参考文献14

  • 1Stern DM, Yan SD, Yan SF, et al. Receptor for advanced glycation endproducts(RAGE) and the complications of diabetes. Ageing Res Rev,2002,1:1-15.
  • 2Ohgami N, Nagai R, Ikemoto M, et al. CD36, serves as a receptor for advanced glycation endproducts (AGE). J Diabetes Complications, 2002,16: 56-59.
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同被引文献24

  • 1杨志明,伍晓汀,何涛.Galectin-3与肿瘤转移[J].中国普外基础与临床杂志,2005,12(3):310-313. 被引量：21
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  • 3PUGLIESE G,PRICCI F,LETO L,et al.The diabetic milieu modulates the AGE-receptor complex in the mesangium by inducing or up-regulating galectin-3 expression[J].Diabetes,2000,49:1249-1257.
  • 4PUGLIESE G,PRICCI F,IACOBINI C,et al.Accelerated diabetic glomerulopathy in galectin-3/AGE receptor 3 knock-out mice[J].FASEB J,2001,15:2471-2479.
  • 5FRIEDMAN E A.Renal syndromes in diabetes[J].Endocinol Metab Clin North Am,1996,25:293-324.
  • 6SINGH R,BARDEN A,MORI T,et al.Advanced glycation end products:a review[J].Diabetologia,2001,44:129-146.
  • 7VLASSARA H,LI Y M,IMANI Y,et al.Identification of galectin-3 as a high-affinity binding protein for advanced glycosylation end products (AGE):a new member of the AGE-receptor complex[J].Mol Med,1995,1:634-646.
  • 8SEKI N,HASHIMOTO N,SANO H,et al.Mechanisms involved in the stimulatory effect of advanced glycation end products on growth of rat aortic smooth muscle cells[J].Metab,2003,52:1558-1563.
  • 9ZHU W,SANO H,NAGAI R,et al.The role of galectin-3 in endocytosis of advanced glycation end products and modified low density lipoproteins[J].Biochem Biophys Res Commun,2001,280:1183-1188.
  • 10KIKUCHI Y,KOBAYASHI S,HEMMI N,et al.Galectin-3-positive cell infiltration in human diabetic nephropathy[J].Nephrol Dial Transpl,2004,19:602-607.

引证文献2

二级引证文献6

国外医学（内分泌学分册）
2005年 第B04期

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