TNF-α与糖尿病视网膜病变关系的研究进展
摘要
糖尿病视网膜病变(DR)是糖尿病最严重的并发症之一。DR患者全身和眼部均可发现肿瘤坏死因子(TNF)-α的活化。TNF-α通过活化核因子、N乙酰葡萄糖胺转移酶,减弱一氧化氮的生物活性,增加血管内皮生长因子、细胞间黏附分子的表达及活性氧簇的产生而参与DR的发生、发展。非甾体类抗炎药可抑制TNF-α的产生,预防早期DR。
出处
《国外医学（内分泌学分册）》
2005年第B04期37-39,共3页
Foreign Medical Sciences(Section of Endocrinology)
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