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PPARγ与甲状腺相关性眼病 被引量：1

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摘要 过氧化物酶体增殖物激活受体(PPAR)γ主要在脂肪细胞内表达,是脂肪细胞分化的一个主要调节因子。而眶内脂肪组织的堆积对甲状腺相关性眼病(TED)的发病有重要作用。最近研究证实PPARγ与TED的发病有关,PPARγ激动剂罗格列酮对眶内成纤维细胞脂肪化起重要作用,而PPARγ拮抗剂GW9662则可抑制脂肪细胞的形成,从而提出PPARγ拮抗剂抑制眶内脂肪形成的概念,这可能为TED的治疗提供新的方向。
作者 周瑜琳 赵咏桔
机构地区 上海第二医科大学附属瑞金医院内分泌科
出处 《国外医学（内分泌学分册）》 2005年第B04期54-56,共3页 Foreign Medical Sciences(Section of Endocrinology)
关键词 PPARΓ 甲状腺相关性眼病 脂肪细胞 细胞分化 2型糖尿病
分类号 R771.3 [医药卫生—眼科]
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参考文献14

  • 1Smith TJ, Hoa N. Immunoglobulins from patients with Graves' disease induce hyaluronan synthesis in their orbital fibroblasts through the selfantigen, insulin-like growth factor- Ⅰ receptor. J Clin Endocrinol Metab,2004,89: 5076-5080.
  • 2Baker GR, Ludgate M. Thyrotropin receptor activation reduces proliferation and has a biphasic effect on differentiating orbital preadipocytes.Invest Ophthalmol Vis Sci, 2004,45: 710.
  • 3Way JM, Harrington WW, Brown KK, et al. Comprehensive messenger ribonucleic acid profiling reveals that peroxisome proliferator-activated receptor gamma activation has coordinate effects on gene expression in multiple insulin-sensitive tissues. Endocrinology,2001,142:1269-1277.
  • 4Uchimura K, Nakamuta M, Enjoji M, et al. Activation of retinoic X receptor and peroxisome proliferator-activated receptor-gamma inhibits nitric oxide and tumor necrosis factor-alpha production in rat Kupffer cells. Hepatology, 2001,33: 91-99.
  • 5Wright HM, Clish CB, Mikami T, et al. A synthetic antagonist for the peroxisome proliferator-activated receptor inhibits adipocyte differentiation. J Biol Chem,2000,275:1873-1877.
  • 6Hihi AK, Michalik L, Wahli W. PPARs: transcriptional effectors of fatty acids and their derivatives. Cell Mol Life Sci,2002,59:790-798.
  • 7Valyasevi RW, Harteneck DA, Dutton CM, et al. Stimulation of adipogenesis, peroxisome proliferator-activated receptor-gamma (PPARgamma), and thyrotropin receptor by PPARgamma agonist in human orbital preadipocyte fibroblasts. J Clin Endocrinol Metab, 2002,87:2352-2358.
  • 8Rangwala SM, Lazar MA. Transcriptional control of adipogenesis. Ann Rev Nutr, 2000,20: 535-559.
  • 9Smith TJ, Koumas L, Anne MG, et al. Orbital fibroblast heterogeneity may determine the clinical presentation of thyroid-associated ophthalmopathy. J Clin Endocrinol Metab, 2002,87: 385-392.
  • 10Mimura LY, Villares SM, Monteiro ML, et al. Peroxisome proliferatoractivated receptor-gamma gene expression in orbital adipose/connective tissues is increased during the active stage of Graves' ophthalmopathy.Thyroid, 2003,13: 845-850.

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国外医学（内分泌学分册）
2005年 第B04期

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