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多内分泌腺瘤病1型的研究进展 被引量:1

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摘要 多内分泌腺瘤病1型是由MEN1抑癌基因失活所导致的肿瘤综合征。近年来的研究已认识到其临床表型多样且具有遗传异质性,远突破于以往认识的经典三联征。MEN1基因需经历两次突变才能导致肿瘤发生,可能的机制是参与调控转录水平的menin蛋白失活所致。对患者及其亲属进行MEN1基因的突变检测有助于早期明确诊断。
出处 《国外医学(内分泌学分册)》 2005年第B04期70-72,共3页 Foreign Medical Sciences(Section of Endocrinology)
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