格列吡嗪控释片对2型糖尿病患者血管内皮功能的影响

Effects of Glipizide-XL on the Endothelium-dependent Relaxing Function of Brachi al Artery in Patients with Type 2 Diabetes Mellitus.

目的 探讨格列吡嗪控释片对2型糖尿病患者血管内皮功能的影响。方法 76例2型糖尿病者,经2周洗脱期后,随机分为两组。一组4 0例应用格列吡嗪控释片;另一组36例应用格列本脲。根据达到目标血糖调整药物剂量,单药未能达标者加用阿卡波糖,治疗期12周。每位患者均采用高分辨率超声显像法,分别于治疗前后各进行一次右肱动脉血管内皮功能检测。结果 格列本脲组治疗前后肱动脉内径基础值、反应性充血及含服硝酸甘油后肱动脉内径变化,均无显著性差异[(3. 70±0 . 5 7)mm对(3 .72±0 . 5 9)mm ,(5 . 4 6±0 .82 ) %对(5 .70±0 .84 ) % ,(2 0 . 5±5 . 0 ) %对(2 0 . 1±5 . 1) % ,P >0 .0 5 ]。格列吡嗪控释片组治疗前后肱动脉内径基础值、含服硝酸甘油后肱动脉内径的变化,也无显著性差异[(3 .72±0 . 6 2 )mm对(3 .73±0 . 6 3)mm ,(19. 8±5. 5 ) %对(19. 9±5 . 8) % ,P >0 . 0 5 ];但反应性充血引起肱动脉内径变化,治疗前后具有非常显著性差异[(5. 6 7±0 .79) %对(9. 4 6±3 .81) % ,P <0 . 0 1]。结论 格列吡嗪控释片可能改善2型糖尿病者的血管内皮功能。

Objective To study the effect of glipizide-XL on en dothelium-dependent relaxing function in type 2 diabetic patients. Metho ds After 2 weeks' run-in, 76 patients with type 2 diabetes mellitus were randomly divided into two groups. They were administrated glipizide-XL(glipizid e-XL group) or glyburide(glyburide group) for 12 weeks. According to the status of blood glucose, some of them were added acarbose. Endothelium-dependent relaxi ng function of brachial artery was measured with B-mode ultrasound in all patien ts before and after treatment. Results In glyburide group, t here was no significant difference before and after treatment in baseline, respo nse to nitroglycerin and responsive congestion in brachial artery endothelium-de pendent relaxing function[(3.70±0.57)mm vs (3.72±0.59)mm,(5.46±0.82)% vs (5.70±0.84)%, (20.0±5.0)% vs(20.1±5.1)%,P>0.05 respectively ]. In glipizide-XL group, there was no significant difference before and after treatment in baseline and response to nitroglycerin in brachial artery endotheli um-dependent relaxing function[(3.72±0.62)mm vs (3.73±0.63)mm,(19.8±5 .5)% vs (19.9±5.8)%, respectively, P>0.05]. But there was significant difference in responsive congestion in brachial artery endothelium-dependent re laxing function before and after treatment[5.67±0.79)% vs (9.46±3.81)%, P<0.01]. Conclusions Treatment with glipizide-XL can improve endothelium function in patients with type 2 diabetes mellitus.