嗜麦芽窄食单胞菌的耐药性分析

Antibiotic resistance and minimum inhibitory concentration distribution of Stenotrophomonas maltophilia

目的 分析临床分离的嗜麦芽窄食单胞菌的耐药性及MIC分布,为嗜麦芽窄食单胞菌感染临床合理应用抗菌药物提供依据。方法 采用琼脂二倍稀释法测定四川大学华西医院收集到的103株临床分离的嗜麦芽窄食单胞菌对8 种抗菌药物的MIC。结果 103株嗜麦芽窄食单胞菌对多种常用抗菌药物呈现多重耐药,但对复方磺胺甲噁唑、替卡西林克拉维酸、环丙沙星、左氧氟沙星和加替沙星的耐药率较低,分别为34.0%、16.5%、26.2%、5.8%和4.9%。结论 对嗜麦芽窄食单胞菌引起的感染应尽早进行病原学检查,并在其药物敏感试验结果指导下选用合适的抗菌药物。

Objective To analyze the antibiotic resistance and distribution of minimum inhibitory concentrations (MIC) of S. maltophilia and provide useful reference for rational antibiotic treatment of S. maltophilia infection. Methods MIC of 8 antibiotics against S. maltophilia were determined using two-fold agar dilution method.Results A total of 103 strains of S. maltophilia were multi-drug resistant. The resistance rate of S. maltophilia to trimethoprim-sulfamethoxazole, ticarcillin-clavavulanic acid, ciprofloxacin, levofloxacin and gatifloxacin were lower (34.0%, 16.5%, 26.2%, 5.8% and 4.9% respectively).Conclusions The pathogen should be isolated as early as possible when S. maltophilia infection is suspected. Antibiotic therapy for S. maltophilia infection should be appropriate based on susceptibility testing and MIC results.