756例反复自然流产患者的染色体核型分析

Analysis on the chromosome karyotypes of 756 patients with the habitual abortion

目的探讨外周血染色体数目和结构异常与死胎、畸形、反复自然流产的关系, 为产前检查和预防流产提供科学根据。方法对武汉市东西湖区妇幼保健院和武钢总医院妇产科门诊1990 年1 月至2003 年8 月就诊的756例反复自然流产患者外周血做淋巴细胞培养, 进行染色体核型分析。结果 756 例患者共检出异常核型27例。其中, 平衡易位10例、罗伯逊易位4例、9 号臂间倒位6 例、嵌合体6 例、Yq+ 1 例; 其中女性17 例,占异常核型62 .96%; 男性10例, 占异常核型37 .04%。结论染色体核型异常是导致死胎、畸形、习惯性流产的重要原因之一; 进行细胞学遗传学染色体检查, 有助于这类夫妇的生育指导。

Aim: To probe the relationships between the stillbirth tetus, teratism, habitual abortion and the abnormal number and constitution of chromosome in the patients' peripheral blood in order to provide scientific supports for antenatal care and prevent abortion. Methods: By investigate 756 outpatients with habitual abortion in Dongxihu District Maternity and Child Care Hospital in Wuhan and General Hospital of Wuhan Iron and Steel Company from Jan. 1, 1990 to Aug. 31, 2003. Their peripheral Lymphocytes were cultured and the abnormal karyotypes were analyzed. Results: There were 27 cases of abnormal karyotype in 756 patients with habitual abortion. Of which, 10 cases were balanced translocation; 4, Robersonian translocation; 6, pericentric in number 9; 6, chimera; and 1, Yq +; and there were 17 cases in the female (accounting for 62.96%) and 10 in the male (amounting to 37.04%). Conclusion: The abnormal karyotype is the most one of important reasons which causes the stillbirth tetus, teratism and habitual abortion. It is benefit to intruct those couples' procreation to investigate chromosome by cytogenetics' mehtods.