骨质疏松症危险因素的病例-对照研究

A Case control Study on Risk Factors for Osteoporosis

目的探索骨质疏松症的可能危险因素,为今后开展骨质疏松症的预防提供参考。方法对经双能X线骨密度测量仪测定并经临床医师确诊为骨质疏松症的348例患者和210例对照进行病例-对照研究。资料分别用单变量和多变量统计方法分析。结果单因素Logistic回归显示,年龄、饮食史、婚姻状况、吸烟、饮酒、睡眠时间、工作类型、疾病史、骨折史有统计学意义(P<0.05)。多因素分析结果显示,年龄、工作类型、婚姻状况、文化程度、饮食饱食程度、动物蛋白与骨质疏松症有关联,居住地、骨折及孕次与女性骨质疏松症有关联。结论骨质疏松症受多种因素的影响,避免高蛋白饮食及女性年轻时控制孕次可能减少骨质疏松症的发生,而经常户外活动可能对骨质疏松症有保护作用,降低骨质疏松症发病的危险性。老年人更应注意骨质疏松症的预防。

Objective To investigate the risk factors for osteoporosis and to make measures for osteoporosis precaution Methods A case control study was carried out in Jangxi province from October 2001 to June 2003. A total number of 348 cases with osteoporosis were identified by clinical doctor with their Bone Mineral Density BMD and 210 controls were selected in the second afiliated hospital of jiangxi Medical College. The bone mineral density BMD was measured by dual energy X ray absorptiometry DXA. Data were analyzed by statistics of chi square test and logistic regression. Results Multiple Logistic regression showed that age marriage status animal protein intake the degree of satiation level of education might be the risk factors for osteoporosis. Conclusion Multiple factors may impact on the osteoporosis. It might reduce the incidence of osteoporosis by controlling the amount of diet proteins and increasing manual labor.