重症哮喘急性发作期甲基泼尼松龙的脉冲疗法

Pulse therapy of methylprednisolone for severe asthma patients at acute attack

目的 观察大剂量甲基泼尼松龙治疗重症哮喘急性发作期患者的临床疗效。方法 38例重症哮喘急性发作期患者按激素的不同剂量及类型分为3组:A组甲基泼尼松龙3d量(1 740±300);B组甲基泼尼松龙3d量(300±180)mg;C组琥珀酸钠氢化可的松3d量(1 000±300)mg。结果 各组患者发病年龄、病程及哮喘严重程度无显著差异。A组症状和体征的改善时间平均为(7. 0±3. 8)d;第一秒用力呼气量与用力肺活量比值为(76±16)%,呼气流量峰值为(581. 74±124. 71)L/s,均显著优于其他各组(P<0. 05)。结论 甲基泼尼松龙脉冲疗法对重症哮喘急性发作期患者具有显著疗效,且毒副作用少。

Objective To investigate the clinical therapeutic effect of large dose of methylprednisolone for the severe asthma patients at acute attack.Methods 38 cases of severe asthma at acute attack were divided into 3 groups according to the different doses of methylprednisolone: group A( dose of methylprednisolone(1 740±300)for 3 days),group B[dose of methylprednisolone(300±180)mg for 3 days]and group C[dose of hydrocortisone (1 000±300)mg for 3 days].Results There was no significant difference in age,the duration of asthma,and the severity of asthma.The improvement time of symptoms and signs were(7.0±3.8)days in group A.FEV_1% and PEF were(76±16)% and(581.74±124.71)L/S,which were superior to those in other groups(P<0.05).Conclusion The pulse therapy of methylprednisolone is of great therapeutic effect in severe asthma patients at acute attack ,with less side effects.