螺旋藻对动物矽肺模型体内抗氧化水平的影响

Effect of spirulina on antioxidation of experimental silicosis of rat

目的研究螺旋藻对动物矽肺模型体内抗氧化水平的影响。方法实验设空白对照组、染尘组和染尘螺旋藻组,用非暴露式气管注入方法复制大鼠矽肺模型,饲养12周。结果螺旋藻能够显著提高染尘大鼠体内超氧化物歧化酶和谷胱苷肽过氧化物酶的活性,降低肺组织中丙二醛的含量和支气管肺泡灌洗液中乳酸脱氢酶、酸性磷酸酶的含量。结论螺旋藻具有提高矽肺动物模型体内抗氧化水平的作用。可在一定程度上延缓或抑制矽肺病变的发展,作用的机制可能与含有丰富的微量元素硒(Se)和β-胡萝卜素等营养成分有关。

Objective To explore the effect of spirulina on antioxidation of silicosis.Methods The silicosis model was prepared by non-exposure brnchus injection,rats were divided randomly into three groups:control group,silica group and spiruina+silica group.Results Spirulina could significantly elevate the activitty of SOD and GSH-Px of the silica exposed rats,meantime could reduce the content of MDA in lungs and ACP,LDH in BALF.Conclusion Spriulina possessed the ability of enhancing the antioxidation level of silicosis rat in vivo,partly restraining the development of silicosis;the mechainsm of the effect probably related to nutritional compositions and such as trace element Se and Betacarotene.