锌和维生素E对糖尿病大鼠内皮细胞保护作用

Protective effects of zinc or/and vitamin E supplement on edothelial cells in diabetic rats

目的探讨锌(Zn)和维生素E(VE)对链脲佐菌素(STZ)诱导的糖尿病(DM)大鼠氧化应激及内皮细胞的保护作用。方法对STZ诱导的糖尿病大鼠模型,补充Zn和VE,6周后观察血糖、血清胰岛素、血清总抗氧化能力(T-AOC)、血清丙二醛(MDA)、血浆血栓素B2(TXB2)、6-酮-前列腺素F1α(6-k-PGF1α)和内皮素(ET)变化。结果Zn和VE可以降低血糖、MDA、TXB2和ET水平,同时提高血清胰岛素水平、T-AOC和血浆6-k-PGF1α水平。结论补充Zn和VE可以减轻糖尿病大鼠氧化应激,保护内皮细胞,影响血浆TXB2、6-k-PGF1α和ET水平。

Objective To study the protective effects of zinc and vitamin E on oxidative stress and endothelial cells in STZ-induced diabetic rats.Methods Streptozotocin-induced diabetic rats were supplemented with zinc and vitamtn E for six weeks.Blood glucose,insulin,MDA and T-AOC in serum,plasma levels of TXB-2,6-k-PGF_~1α and ET were examined.Results In diabetic rats plasma levels of TXB-2 and ET were lowered while blood glucose and MDA were decreased,insulin,T-AOC and plasma levels of 6-k-PGF_~1α were increased by zinc and vitamin E supplement.Conclusion Zinc and vitamin E supplementation reduced oxidative stress,influenced the plasma levels of TXB-2,6-k-PGF_~1α and ET,and had protective effects on endothelial cells in diabetic rats.