老年人血浆维生素K和D水平的季节变化

Seasonal variation of vitamin K and vitamin D status in elderly people

目的了解老年人群血浆维生素K和维生素D水平的季节变化。方法对85名健康老年人用放射免疫分析法测定春秋两季血浆维生素D(25(OH)D)和甲状旁腺素(PTH)含量,用高压液相色谱法测定血浆维生素K含量。结果血浆维生素K水平女性在春秋两季均明显高于男性,而男性和女性各自无季节性差异。无论男女秋季血浆维生素(25(OH)D)水平明显高于春季,同一季节内男女间差异无统计学意义。维生素D缺乏率女性春季为63.4%,秋季为7.3%。男性春季为65.9%,秋季无缺乏者。春季维生素D缺乏率显著高于秋季(P<0.05)。男女秋季血浆PTH浓度明显低于春季。老年女性春季血浆25(OH)D浓度和血浆PTH浓度之间呈负相关(r=-0.426,P<0.001)。结论该人群血浆25(OH)D和PTH有明显的季节变化,春季血浆25(OH)D水平低。而血浆维生素K没有季节变化。

Objective To investigate the seasonal variation of 25-hydroxyvitamin D 〔25(OH)D〕 and vitamin K in elderly people.Methods Plasma 25(OH)D and parathyroid hormone (PTH) of 85 healthy elderly volunteers were measured by radioimmunoassays in spring and autumm.Plasma vitamin K were measured by HPLC.Results The concentration of vitamin K in wowen were significant higher than those in men both spring and autumn,whereas there were no seasonal differences in the concentration of vitamin K of women and men.The concentrations of 25(OH)D in autumn were signincant higher than those in spring.No differences in the concentrations of 25(OH)D between women and men in the same season were found.The rates of vitamin D deficiency were 63.4%,7.3% and 65.9% for women in spring,women in autumn and men in spring respectively.The rate of vitamin D deficiency in spring was significant higher than that in autumn.The concentrations of PTH in autumn were significant lower than those measured in spring.A negative association between PTH and 25(OH)D was found in women in spring (r=-0.426,P<0.01).Conclusion There were seasonal variations in plasma 25(OH)D and PTH in elderly people living in Shenyang.Vitamin D levels in this population were low in early spring.There were seasonal variations in plasma vitamin K in this population.