慢性氯乙烯中毒检测指标的研究

Jin Yuke, et al. Study on diagnostic indi-ces for chronic vinyl chloride poisoning

调查某厂空气氯乙烯浓度在９．４～２０．１ｍｇ／ｍ￣３条件下作业工人的神经肌电图、神经递质、内分泌激素及淋巴细胞染色体Ｇ显带核型分析。结果证明：５０％工人出现以轴索变性为主的亚临床型或轻度中毒性周围神经病变；淋巴细胞染色体畸变率明显增高。在染色休畸变中５０％是缺失，多发断裂点２１ｑ２２，２２ｑ１３、１７ｑ２１与癌基因位点密切相关。以上两项指标可作为氯乙烯中毒早期检测指标。

Electromyography,neurotransmitter,en-docrine hormone and lymphocyte G bandedchromosome analysis were carried out in wor-kers exposed to vinyl chloride of one chemi-cal factory, where atmosphere VC concentra-tion amounted to.4～20.1mg/m￣3. The resultshowed that the subclinieal or slight toxic-peri-pheral neuritis was mainly induced byneuraxis degeneration. The frequencies of lym-phocyte chromosomal aberrations were signi-ficantly increased. The deletion was found in50%of total chromosome aberrations,as wellas, the breaking sites were mainly located at21q22, 22q13, 17q21, which were related tocarcinoma gene sites.Above two kinds of in-dices might be served as tbe diagnOstic indi-cators of the VC poisoning in carly stage andan indicator to supervise malignant transfor-mation,The neurotransmitter and endocrinehormone examination did not show significantchange.