先天性心脏病环境危险因素病例对照研究

Case-control study on environmental risk factors of congenital heart disease

目的 探讨与先天性心脏病 (CHD)发生有关的环境危险因素 ,为CHD的人群预防措施的制订提供科学依据。方法 采用以医院为基础的 1 :2配比病例对照研究方法。对照匹配条件为同性别、同一居住地区与出生日期相差 6个月。采用单因素及多因素Logistic回归分析方法对 5 0个变量进行分析。结果 母亲孕期接触有毒化学物(OR =1 2 991 )、有负性生活事件 (OR =8 6 38)、感冒发烧 (OR =4 92 9)、服用抗生素 (OR =3 6 92 )与CHD的发生呈正相关 ,孕期多食肉、蛋、豆、奶类食物 (OR =0 1 4 1 )与CHD的发生呈负相关。结论 母亲孕期接触有毒化学物、有负性生活事件刺激、感冒发烧、服用抗生素是CHD发生的危险因素 ,孕期多食肉、蛋、豆、奶类食物是CHD的保护因素。

Objective To determine environmental risk factors in the development of congenital heart disease(CHD) and to provide scientific evidence for the decision of making population intervention measures. Methods A hospital-based 1:2 matched case-control study was conducted.Each case was matched with two normal controls on the sex, living district,birth date before or after half one year.By means of simple and multivariable conditional Logistic regression,50 factors were analyzed.Results Maternal exposure to poisonous chemicals,negative life events, cold with fever,taking antibiotic medicine,much consumption of meat,eggs,beans and milk during pregnancy were significantly associated with CHD and their odds ratios(OR) were 12.991,8.638,4.929,3.692,0.141,respectively.Conclusion Maternal exposure to poisonous chemicals,negative life events,cold with fever,taking antibiotic medicine during pregnancy were the key environmental risk factors contributing to CHD,while maternal exposure to much consumption of meat,eggs,beans and milk during pregnancy was a protective factor for CHD.