摘要
目的 探讨邻苯二甲酸二丁酯 (di -n -butylphthalate,DBP)和邻苯二甲酸二辛酯 (di- n -octylphthalate,DOP)对果蝇生存时间的影响和遗传毒性。方法 用等质量混合的DBP和DOP对果蝇经口联合染毒 ,采用果蝇寿命试验和果蝇伴性隐性致死试验观察DBP、DOP对果蝇生存时间的影响对生殖细胞的致突变作用。结果 从 0 . 2 %浓度组开始 ,果蝇平均寿命与对照组相比差异有统计学意义 ,6 0 0 ,180 0mg/L浓度组果蝇突变率与对照组相比差异有统计学意义。结论 DBP、DOP干扰了果蝇正常的生长发育和新陈代谢 ,并加速其衰老 ;DBP、DOP对果蝇生殖细胞有致突变作用。
Objective To study the influence of phthalic acid ester on drosophila's life span and mutagenesis to drosophila's germ cell.Methods In drosophila's life span test and SLRL flies were fed with di-n-butyl phthalate(DBP)and di-n-octyl phthalate(DOP)of identical concentration.Results Above concentration of 0.02% group flies'life span became obviously shorter compared with the control group;mutation rate of flies in 600,1800mg/L group remarkably differed from that of the control group. Conclusion DBP and DOP interfered flies' natural development and metabolism,shortened flies' life span obviously;DBP and DOP also had mutagenic effect on Drosophila's germ cell.
出处
《中国公共卫生》
CAS
CSCD
北大核心
2005年第4期432-433,共2页
Chinese Journal of Public Health
关键词
酞酸酯
果蝇
寿命
遗传毒性
phthalic acid ester
drosophila
life span
mutagenesis
