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Production of radioactive ~9C ion beam and its optimization 被引量:3

Production of radioactive ~9C ion beam and its optimization
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摘要 To explore the medical use of a radioactive 9C-ion beam in tumor treatment, which is a double radiation source coming from the external beam itself and the delayed particles emitted internally, some physical experiments are performed at the Secondary Beam Line (SBL) of Heavy Ion Medical Accelerator, Chiba (HIMAC) in Japan be- fore radiobiological research for exhibiting therapeutic value of the 9C beam. Intention of the experiments is for pro- ducing a radioactive 9C-ion beam with higher production rate and purity by means of optimizing the beam line pa- rameters. Finally, a produced 9C beam with the production rate of 9.07×10-6 and purity of 82.88% at full momentum acceptance has been obtained under the optimal conditions of 40 mm-thick beryllium target and 10 mm-thick alumi- num degrader. Both momentum distribution and contaminations for the produced 9C beam under the optimal condi- tions are measured. In order to execute further biological experiments of the 9C beam project, a uniform irradiation field is made with the wobbling magnets and its homogeneity is up to 93.8% inside central area of 20mm in diameter. To explore the medical use of a radioactive 9C-ion beam in tumor treatment, which is a double radiation source coming from the external beam itself and the delayed particles emitted internally, some physical experiments are performed at the Secondary Beam Line (SBL) of Heavy Ion Medical Accelerator, Chiba (HIMAC) in Japan be- fore radiobiological research for exhibiting therapeutic value of the 9C beam. Intention of the experiments is for pro- ducing a radioactive 9C-ion beam with higher production rate and purity by means of optimizing the beam line pa- rameters. Finally, a produced 9C beam with the production rate of 9.07×10-6 and purity of 82.88% at full momentum acceptance has been obtained under the optimal conditions of 40 mm-thick beryllium target and 10 mm-thick alumi- num degrader. Both momentum distribution and contaminations for the produced 9C beam under the optimal condi- tions are measured. In order to execute further biological experiments of the 9C beam project, a uniform irradiation field is made with the wobbling magnets and its homogeneity is up to 93.8% inside central area of 20mm in diameter.
出处 《Nuclear Science and Techniques》 SCIE CAS CSCD 2005年第2期95-98,共4页 核技术(英文)
基金 Supported by NIRS-HIMAC(Subject No.15P150)
关键词 放射性离子束 参数优化 肿瘤治疗 放射医学 Radioactive ion beam,Production,Optimizing parameter,Tumor treatment
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参考文献4

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同被引文献16

  • 1WEIZengquan,LIQiang,A.Kitagawa,T.Kanai,M.Kanazawa,Y.Furusawa,E.Urakabe,XIEHongmei,ZHOUGuangming.Biological effects of radioactive ~9C-ion beams on cells[J].Chinese Science Bulletin,2005,50(11):1070-1075. 被引量:2
  • 2[1]BACOVAG E,HUNAKOVA L,CHORVATH M,et al.Radiation induced DNA damage and repaire valuated with comet assay in human varian carcinoma cell lines with different radio sensitivities[J].Neoplasma,2000,47(6):367-374.
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  • 5方允中 刘智峰 李益新.γ射线离体照射对铜、锌、超氧化物岐化酶理化性质的影响.科学通报,1984,29:943-943.
  • 6Shkala LV. Correction of trace element metabolism in patients with breast cancer during radiation therapy [J]. Vopr Onkol, 1997, 43 : 273.
  • 7Phillips JL, Ivaschuk OI, Ishida-Jones T, et al. DNA damage in Molt-4 T-lymphoblastoid cells exposed to cellular telephone radiofrequency fields in vitro [J]. Bioelectrochem Bioenerg, 1998, 45: 103-110.
  • 8王沭沂,陈永娟,陈宇炼.微波辐射对小鼠睾丸中微量元素水平的影响[J].南京医科大学学报(自然科学版),1997,17(5):448-449. 被引量:6
  • 9邓春富,杨彦昌,孙长伏.^(60)Co-r射线照射犬下颌骨对血清中微量元素的影响[J].现代口腔医学杂志,1999,13(2):128-129. 被引量:3
  • 10王敏.细胞周期素与卵巢肿瘤[J].国外医学(妇产科学分册),2000,27(4):220-224. 被引量:3

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