宽舌橐吾的化学成分研究

Study on the Chemical Constituents of Ligularia platyglossa (Franch.) Hand .-Mazz.

目的:研究宽舌橐吾(Ligulariaplatyglossa (Franch )Hand -Mazz )的化学成分,发现生物活性成分,为其资源开发利用奠定化学基础。方法:采用硅胶柱、SephadexLH 2 0柱和Rp 18反相柱层析法分离、重结晶纯化化合物,根据理化性质和波谱数据鉴定化合物结构。结果:从宽舌橐吾的根和根茎中分得艾里莫芬烷型倍半萜内酯类、黄酮类、苯甲酸类和吡咯里西啶生物碱类等7个已知化合物,分别为:Eremophil 1(10 ) ,7(11) ,8(9)- trien 12 ,8- olide(1) ;8βHydroxy eremophil- 7(11) ,9(10 )- dien 12 ,8α- olide(2 ) ;2 - Oxo eremophil 1(10 ) ,7(11) ,8(9) - trien -12 ,8- olide(3) ;黄颜木素(Fisetin) (4) ;异香草酸(Isovanillicacid ,即3 -Hydroxy- 4 - methoxy benzoicacid) (5 ) ;7- Angelyhe -liotridine(6 ) ;胡萝卜苷(7)。结论:以上化合物均为首次从宽舌橐吾中分得,其中化合物2～6为首次从橐吾属中分得,化合物3为新的天然产物。

AIM:To find out bioactive compounds from Ligula ria pl atyglossa. METHOD: Compounds were isolated by silica gel, Sep hadex LH-20 and Rp-18 column chromatography,and purified by recrystallizati on . Their structures were identified by NMR spectral data and other methods. RESULT: Seven compounds were isolated and identified as Eremophil-1( 10),7(11),8(9) -trien-12,8-olide (1); 8β-Hydroxy-ere mophil-7(11),9(10)) -dien-12,8α-olide (2);2-Oxo-erem ophil-1(10),7(11),8(9) -trien-12,8-olide (3);Fisetin (4); Isovanillic acid (5);7-Angelyhelio tridine (6) and Daucosterol (7), respective ly.CONCLUSION: All of the compounds were isolated from this plant for the first time and compounds 2, 3, 4, 5 and 6 were isolated from Ligularia genus for the first time. Compound 3 was a new natural entity.