周围动脉硬化闭塞症在老年血脂异常人群中的现患率调查

The prevalence of peripheral arteriosclerotic occlusive disease in elderly population with hyperlipemia

目的 了解周围动脉硬化闭塞症 (PAOD)在老年血脂异常人群中的现患率。方法 北京市万寿路地区老年居民 2 0 4 11位中 ,以家委会为单位 ,整群随机抽样抽得 2 12 4例。周围动脉硬化闭塞症的诊断以踝肱动脉压力指数(Ankle Armindex ,AAI)≤ 0 .9为标准 ;对血脂异常的诊断采用美国胆固醇教育计划 (NCEP)成人治疗第三次报告(ATPⅢ )提供的参考标准即满足下列 4条之一者为血脂异常的诊断标准 :甘油三酯 (TG)≥ 2 .2 6mmol L ,总胆固醇(TC)≥ 5 .72mmol L ,低密度脂蛋白 (LDL)≥ 3.6 4mmol L ,高密度脂蛋白 (HDL)≤ 1.0 4mmol L。结果 血脂异常患者为 10 71例 ,男 4 10例 ,女性 6 6 1例 ,年龄 6 0～ 92 (6 8.3± 5 .4 )岁 ,现患率为 5 0 .4 2 % ;其中PAOD 184例 ,现患率为17.18% ,男 6 0例 ,女 12 4例 ;PAOD在各类血脂异常患者中的患病率分别为 :高TG血症 14 .12 % ;高LDL血症10 .10 % ;高TC血症 15 .94 % ;低HDL血症 19.6 5 % ;血脂异常合并高血压患者 19.18% ;高血压患者 14 .98% ;血脂异常合并糖尿病患者 19.4 76 % ;糖尿病患者 15 .38% ;高龄血脂异常患者 4 2 .86 %。结论 HDL降低是PAOD的独立的危险因素 ;各型血脂异常对PAOD现患率的影响没有差异 ;血脂异常合并其他危险因素将明显增加PAOD的现患率 ;

Objective To investigate the prevalence of peripheral arteriosclerotic occlusive disease(PAOD) in elderly population with hyperlipemia.Methods A cross-sectional survey of PAOD was made in the Wanshoulu area, Beijing. A total of 2?124 subjects were studied. PAOD was defined as an ankle-arm index(AAI)≤0.9. Hyperlipemia was diagnosed with the reference standard provided by ATPⅢ,which accord with one of four standards listed below: TG≥2.26 mmol/L,TC≥5.72 mmol/L, LDL≥3.64 mmol/L, HDL≤1.04 mmol/L.Results There were a total of 1?071 patients with hyperlipemia,including 410 males and 661 females, aged 60～92 (68.3±5.40) years, and the prevalence rate was 50.42%.Of them,60 males and 124 females had PAOD and the prevalence rate was 17.18%. The prevalence rates of hypertriglyceridemia, elevated LDL,hypercholesterolemia, reduced HDL, hyperlipemia and hypertension, hypertension, hyperlipemia and diabetes mellitus, diabetes mellitus, advanced age and hyperlipemia in the population with PAOD were 14.12%, 10.10%,15.94%, 19.65%, 19.18%, 14.98%, 19.476%, 15.38%, and 42.86% respectively.Conclusions The decrease in HDL was the independent risk factor of PAOD. The prevalence of PAOD showed no difference among all kinds of hyperlipemia. The prevalence of PAOD will be increased significantly in patients with hyperlipemia combined with other risk factors. The prevalence of PAOD in patients with advanced age and hyperlipemia was 2～3 times higher than that in ordinary elderly patients.