左旋氧氟沙星联合治疗耐药性肺结核临床效果观察

Clinical effection of levofloxacin for joint treatment of endure tuberculosis

目的探讨左旋氧氟沙星在耐药性肺结核治疗中的作用。方法对80例耐药性肺结核患者分成两组(观察组与对照组,每40例为一组),分别使用耐药性抗痨治疗方案。观察组用Pa+EM B+PZ A+K m+LVFX含左旋氧氟沙星治疗方案;对照组用Pa+EM B+PZA+Km不含左旋氧氟沙星治疗方案;两组均治疗3个月后停PZA,继续跟踪治疗9个月,两组疗效比较。结果观察组39例患者症状消失;38例病灶有明显吸收好转;痰集菌转阴率63%,与对照组比较差异有显著性。结论左旋氧氟沙星在耐药性肺结核治疗中有着重要作用。

To explore the effects of Levofloxacin on the treatment of drug-resistant pulmonary tuberculosis. 80 cases of drug-resistant pulmonary tuberculosis were equally divided into 2 group (therapentic group and contrast group, n =40). The Pa+EMB+PZA+Km+LVFX which contain the levofloxacin were used in the therapentic group, whereas the Pa+EMB+PZA+Km which dose not contain the levofloxacin were used in the contrast group; After the treatment of 3 months, the PZA was stopped in both groups, and for nine months, After comparing the effect of 2 group. The symptoms of 39 cases were disappeared, the tuberculosis focus were absorbed obviously in 38 cases. The rate of negative tuberculosis in sputum reached 63%. The results of therapentic group were better than those of contrast group. [Conclusion] The levofloxacin plays an important role on the treatment of drug-resistant pulmonary tuberculosis.