糖脂康胶囊的毒性评价及临床观察

The evaluation of the toxicity and clinical curative observation of Tangzhikang capsulesD

目的考察糖脂康胶囊的急性毒性并观察其临床降脂、降糖作用。方法通过LD50 和最大耐受量的测定,考察糖脂康胶囊的急性毒性。对180例服用糖脂康胶囊的患者临床观察4～5周,分别测定治疗前后的血清总胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、空腹和餐后2h血糖,评价其治疗效果。结果急性毒性试验表明,糖脂康胶囊毒性极低,无法测得LD50 。小鼠1dig糖脂康胶囊的最大耐受量大于4 8g/kg ,最大耐受量为人临床用量(0 .0 75g/kg)的6 4 0倍。临床降脂、降糖作用明显,疗效可靠,无明显不良反应。结论糖脂康胶囊是一种安全有效的降脂。

PurposeTo evaluate of the toxicity and observe the clinical curative effects for reducing blood lipoprotein and blood sugar of Tangzhikang capsules.MethodsThe acute toxicity test of Tangzhikang capsules were done by the way of measuring LD_(50) and the maximum tolerant quantity。The clinical curative effects of Tangzhikang capsules were evaluated in 180 patients by taking oral administration for 4～5 weeks as a period, the TC,TG, HDL-C, LDL-C, FBS, and 2h-BS were measured respectively before treatment and after treatment.ResultsThe acute toxic test showed that the acute toxicity of Tangzhikang capsules were too low to measure LD_(50). The maximum tolerant quantity for mice ig / day was more than 48 g/kg, which was 640 times according with the clinical dosage of human(0.075 g/kg). The clinical curative effects of this product about reducing blood lipoprotein and blood sugar were obvious and reliable,the severe adverse reaction was not detected.ConclusionTangzhikang capsules was a secure and effective medicine for reducing blood lipoprotein and blood sugar.