衡阳地区淋球菌流行株对抗生素耐药性监测

Surveillance of Antibiotic Resistance of Neisseria Gonorrhoeae in Hengyang

目的 了解衡阳地区淋球菌流行株对抗生素的耐药性及产青霉素酶淋球菌(PPNG)和高水平耐四环素淋球菌(TRNG)的流行状况。 方法 采用琼脂稀释法测定最低抑菌浓度(MIC)以及用改良碘法检测β-内酰胺酶。 结果 10 1株淋球菌共检出PPNG 3 2株(3 1.7% )、TRNG 2 0株(19.8% ) ,对四环素、环丙沙星、青霉素及大观霉素的耐药率分别为94.1%、91.1%、89.1%和2 .0 % ,未发现耐头孢曲松钠的菌株。淋球菌交叉耐药情况较为严重,79.2 %菌株对青霉素和环丙沙星呈现交叉耐药,84.2 %菌株对四环素和环丙沙星呈现交叉耐药。 结论 头孢曲松钠和大观霉素仍可作为衡阳地区淋病治疗的首选药物,但大观霉素已出现耐药株,应引起临床医师的高度警惕;

Objective Surveillance on drug resistance features and prevalence of penicillinase-producing Neisseria gonorrhoeae(PPNG) and highly tetracycline resistant Neisseria gonorrhoeae(TRNG) in Hengyang district. Methods Minimum inhibitory concentration(MIC) were determined by agar dilution method and β-lactamase was detected with the modified iodometric method. Results There were 32(31.7%) PPNG isolates and 20(19.8%) TRNG isolates among the 101 Neisseria gonorrhoeae isolates. The drug resistant rates to tetracycline, ciprofloxacin, penicillin and spectinomycin were 94.1%, 91.1%, 89.1% and 2.0%, respectively. But no Ceftriaxone resist isolate was found. The cross-resistant isolates were prevalent, 79.2% were cross-resistant to penicillin and ciprofloxacin and 84.2% to tetracycline and ciprofloxacin. Conclusions Currently ceftriaxone and spectinomycin can be used as primary agents to cure gonorrhea in Hengyang district, but clinical practitioners need to pay more attention to the emerging spectinomycin resistant strains Continuous monitoring to Neisseria gonorrhoeae drug resistance is required.