老年期重症肌无力的临床特征

Clinical Characteristic Features of Myasthenia Gravis in the Elderly Patients

目的 研究老年期重症肌无力(MG)的临床特点。 方法 将2 0年间诊治的192 4例MG ,根据发病年龄分为小儿期MG(≤14岁)、成年期MG(15～5 9岁)及老年期MG (≥60岁)。采用χ2 检验比较三组的临床资料。 结果 老年期MG在整个MG中只占5 .5 % ,男性发病者较多见(男:女=1.4:1) ,以延髓支配肌肉首发者多见,合并胸腺瘤者多而合并其他自体免疫病者少,以延髓支配肌肉首发而误诊为脑血管病者多见,病死率高,但死于肌无力者少。 结论 老年期MG与成年期、小儿期相比有其独特之处。

Objective To study the clinical characteristic features of myasthenia gravis(MG) in the elderly patients. Methods The patients with MG were divided into three groups based on the onset of disease, which were juvenile MG( ≤14 year-old), adult MG (15～59 year-old) and senile MG (≥60 year-old). The χ 2 test was employed to evaluate the difference of clinical manifestations among these groups. Results (1)There were male predominance (M:F=1.4:1) patients than female ones in the senile MG group. (2) The bulbospinal muscular involvement as the presentation sympton was frequent and misdiagnosis as a cerebrovascular disease in the senile MG group was common. (3) Senile MG was usually associated with thymoma, but less often with other autoimmune diseases. (4)The mortality was higher in the senile GB group, but less common died from myasthenia crisis. Conclusion The senile MG has its unique clinical features. with the availability of important clinical manifestation information, the diagnostic recognition and optimal therapy in the elderly patients with BG might be facilitated.