不同年龄患者腹膜透析的疗效比较

Comparison in Therapeutic Effects of Peritoneal Dialyses between the Patients Different in Age

目的评价老年病人腹膜透析的疗效。方法对已进行透析6个月以上能定期门诊随访的腹膜透析患者,根据年龄分为两组:评估时年龄≥60岁为老年组,年龄<60岁为非老年组。观察两组病人透析前后血压、营养性指标(包括血脂、血红蛋白、血浆总蛋白和白蛋白)、充分性指标(包括Ccr和KT/V)及生存率变化。结果两组病人透析前与透析后比较,血压、血红蛋白和血脂差异无显著性(P>0.05);老年组血浆总蛋白和白蛋白浓度降低,而非老年组无变化;老年组Ccr明显低,其中两组腹膜Ccr无差别,主要是老年组残肾Ccr更低;KT/V两组无差别;两组病人的1年、2年及3年的生存率差异无显著性(P>0.05)。结论腹膜透析简便易行,安全有效,适用于老年病人持续性透析。

Objective To evaluate the therapeutic effect of peritoneal dialyses on elderly patients.Methods The patients who had been given peritoneal dialyses for more than six months were divided into two groups according to their ages, i.e. elderly group (older than or equal to 60 years) and non-elderly group (younger than 60 years). Their indexes such as blood pressure, nutrient parameter (blood lipids, hemoglobin, total plasma protein and plasma albumin), creatinine clearance rate (Ccr) and KT/V, and survival rate were detected before and after dialyses. Results There were no significant differences in blood pressure, blood lipids and hemoglobin between before and after dialyses in the two groups (P>0.05). The total plasma protein and plasma albumin of the elderly group decreased when compared with that before dialyses, while there were not any changes in the other group. Although the Ccr of the elderly group was lower (P<0.05), there was not any difference in peritoneal Ccr. No difference in KT/V existed between the two groups. Also, there were not any differences in 1-, 2- and 3-year's survival rate. Conclusion It is suggested that peritoneal dialysis, which is fit for elderly patients who accept persistent dialysis, is feasible, convenient and safe.