摘要
目的观察急性呼吸窘迫综合征(ARDS)肠损伤中血管紧张素转换酶(ACE),乳酸脱氢酶(LDH)活性和丙二醛(MDA)含量变化,研究ARDS发病机制。方法采用尾静脉注射油酸法复制大鼠ARDS模型,测血清、肠组织匀浆ACE、LDH活性和MDA含量。结果血清、肠组织匀浆ACE,LDH活性和MDA含量均出现变化。结论血浆和组织匀浆中的ACE,LDH活性和MDA含量变化可在一定程度上反映病情的轻重,对预后有一定的提示作用。
Objective To investigate into the alteration of angiotensin converting enzyme (ACE) and lactic dehydrogenase (LDH) activity and malondialdehyde (MDA) content in the small intestine during acute respiratory distress syndrome (ARDS) and explore the mechanism of ARDS.Methods ARDS rat models were established by injecting oleic acid into the veins of the tails. Plasma and the small intestine homogenate's ACE and LDH activity and MDA content were assessed during the experimental hours. Results There were alteration of index in ACE and LDH activity and MDA content.Conclusion The alteration of ACE and LDH activity and MDA content can reflect the condition and forecast the result of the disease to some extent.
出处
《临床军医杂志》
CAS
2005年第2期140-142,共3页
Clinical Journal of Medical Officers
关键词
小肠
大鼠
急性呼吸窘迫综合征
血管紧张素转换酶
乳酸脱氢酶
丙二醛
small intestine, rat
acute respiratory distress syndrome
angiotensin converting enzyme
lactic dehydrogenase
malondialdehyde
