糖尿病患者肝功能的变化及其意义

Variation and Significance of Liver Function in Patients with Diabetic Mellitus

目的观测糖尿病相关性肝损伤的情况。方法对264例糖尿病患者进行总胆红素(TBIL)、直接胆红素(DBIL)、白蛋白(ALB)、丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)、r-谷氨酰转移酶(GGT)和总胆固醇(TC)、甘油三酯(TG)检测。结果糖尿病相关性肝损伤的发生率为28.9%,表现为胆红素、肝酶升高及白蛋白下降,肝酶大多为轻度升高。肝损伤患者TC、TG水平及异常率明显高于肝功正常者。结论糖尿病患者肝损伤较常见,应常规检查肝功能。

Objective To observe the liver injury in patients with diabetic mellitus (DM). Methods 264 patients with DM were selected, and the serum levels, of total bilirubin (TBIL), direct bilirubin (DBIL), albumin (ALB), alanine aminotransferases (ALT), aspartate aminotransferase (AST), gamma-glutamyltransferase (GGT), total cholesterol (TC) and triglyceride (TG), were measured. Results The incidence of liver injury in patients with DM was 28.9%. Bilirubin and enzymes of liver increased, and ALB decreased. The levels and abnormal incidences of TC and TG were higher obviously in patients with liver injury than in those without liver injury. Conclusion Liver injury in DM patients is one of common features and liver function should be measured as routine determination.