丙型肝炎患者治疗前后SOD和T淋巴细胞亚群检测的临床意义

Clinical Significance of Determination of Changes of Serum SOD Levels and T-cell Subgroup Distribution Type After Treatment in Patients with Hepatitis C

目的:探讨了丙型肝炎患者治疗前后血清SOD和T淋巴细胞亚群分布状况的改变。方法:分别应用放射免疫分析和单克隆抗体法对56例丙型肝炎患者的血清SOD水平及T淋巴细胞亚群的检测,并与35名正常健康人作比较。结果:丙型肝炎患者在治疗前血清SOD、T淋巴细胞CD4 /CD8 值水平明显低于正常人组(P<0 01),治疗后3个月,SOD水平与正常人比较无显著性差异(P>0 05)而CD4 /CD8 值水平与正常人组比较仍有显著性差异(P<0 05)。结论:检测丙型肝炎患者血清SOD和T淋巴细胞亚群值水平对其病情和预后判断均有重要的临床价值。

Objective To investigate the changes of serum SOD levels and T-cell subgroup distribution type after treatment in patients with hepatitis C. Methods Serum SOD levels were measured with RIA and T-cell subgroup distribution type detected with monoclonal antibody technic both before and after treatment in 56 patients with hepatitis C and 35 controls. Results Before treatment the serum levels of SOD as well as the CD 4/CD 8 value were significantly lower in the patients than those in controls (P<0.01), After treatment the serum SOD levels in patients were not much different from those in the controls (P>0.05), while the CD 4/CD 8 values were still significantly lower (P>0.05). Conclusion Determination of serum SOD levels and T-cell subgroup distribution type were useful in the study of cellular immunofunction disturbance during recovery in patients with hepatitis C.